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A computational model suggested that this optimum size was determined by the competition between their permeation through opened BBB gaps and their excretion from blood

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Moreover, melatonin activates pyruvate dehydrogenase kinase 4 (PDK4) to regulate acetyl-CoA content ( -oxidation or increasing the transfer of fatty acid-derived acetyl-CoA into mitochondria ( FIGURE 2 Second, melatonin can enhance the activity of the electron-transport chain (ETC) and oxidative phosphorylation (OXPHOS) to regulate mitochondrial metabolism

Promote acetylcholine production (important for memory + cognition) which has the abilityto protect against diseases such as dementiaand Alzheimers

Hypoxia exacerbates this process through an independent mechanism