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Accordingly, the search for BBB-permeant therapeutic drugs is ongoing

NAMPT catalyzes a rate-limiting step in the salvage pathway that regenerates NAD+ from nicotinamide

( A , C ) Heatmap showing the genes that are upregulated and downregulated in A375 and SKMEL-103 cells upon treatment with BAY-850 (5 M) for 48 h compared with the DMSO-treatment