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Vitamin C, a well-known antioxidant, enhances the sensitivity of cancer cells resistant to imatinib by disrupting the Nrf2/ARE complex, resulting in decreased expression of the catalytic subunit of glutamate-cysteine ligase and lower GSH levels (175)

Mass spectrometry-based proteomics reveals that these off-targets are highly abundant proteins (e.g

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68 The increase in cardiac lymphangiogenesis was found to be necessary for exercise-induced physiological cardiac hypertrophy and the increased proliferation markers in cardiomyocytes