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The cytotoxic activity of gliotoxin is generally mediated by direct inactivation of essential protein thiols [4] and by inhibition of the respiratory burst in neutrophils by disrupting NADPH oxidase assembly, thereby facilitating in vivo fungal dissemination [5], [6]

Furthermore, a meta-analysis encompassing 13 studies comprising 1,606 females diagnosed with PCOS revealed that sustained administration of metformin leads to a notable decrease in miscarriage and preterm birth rates, alongside an increase in full-term pregnancies