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Meskipun GSH telah ditemukan pada tahun 1888 oleh De-Rey-Pailhade, tidak sampai tahun 1970 peran detoksifikasinya telah diketahui

The activity of GPX was determined by catalyzing 1 nmol GSH per minute per mg in samples

By neutralizing free radicals and supporting the mucosal barrier, it may help provide a layer of defense that standard treatments often overlook

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Other benefits can be attributed to this and other phenolic compounds in olive such as maintenance of normal blood HDL-cholesterol concentrations, maintenance of normal blood pressure, anti-inflammatory properties, contribution to the upper respiratory tract health, maintenance a normal function of gastrointestinal tract, and contribution to body defenses against external agents, although only a cause-effect relationship between the consumption of olive oil polyphenols and protection of LDL particles from oxidative damage has been firmly recognized ( More conclusive studies are needed to link all these potential benefits with phenolic compounds such as HOTYR and OLE and thus to involve new lines of research into drugs that prevent and treat these diseases