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Further exploration demonstrated that Swell1 overexpression in a mouse microglial cell line, BV2 cells, cultured in a hypotonic environment to activate chlorine channels, activated cAMP response element-binding protein (CREB) and forkhead box O3 (FOXO3a) transcription factors and the negative regulator of the NLRP3 inflammasome, WNK lysine deficient protein kinase 1 (WNK1) (Chen et al., 2023)

Holzem, M., Boutros, M

2 Cysteine depletion triggers metabolic rewiring without altering protein synthesis and iron-sulfur cluster maintenance

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Deciphering the structural determinants critical in attaining the FXR partial agonism