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Description

A deficiency is characterised by megaloblastic anaemia, fatigue, weakness, constipation, loss of appetite, and weight loss

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The clinical case for combining AOD-9604 with GLP-1 therapy in patients who have plateaued is mechanistically coherent (the two compounds act on different sides of the energy balance equation through non-overlapping mechanisms) and is not supported by randomized controlled trial evidence for the specific combination

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doi: 10.1016/j.bmcl.2011.05.022

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Potential Research Applications: Fat Metabolism: In obese animal models (e.g., Zucker rats), AOD 9604 reduced body weight gain by over 50% within 19 days (oral, 500 g/kg daily)

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N., Watts, R., Jacobs, R

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