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The prolonged exposures to dietary TMAO or choline resulted in a significant increase in plasma cystatin C levels in mice, indicating renal dysfunction (Tang et al., 2015b)

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Individuals with BD are therefore often prescribed a combination of therapies in order to improve functional outcomes, with the ultimate goal of reducing the frequency, duration, and severity of episodes and increasing the amount of time spent in remission (Dean et al., 2018)