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These design features yield a pharmacokinetic profile suitable for once-weekly administration, with a reported elimination half life of 78 days (DAscanio et al

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Fox SH, Katzenschlager R, Lim S-Y, Ravina B, Seppi K, Coelho M, Poewe W, Rascol O, Goetz CG, Sampaio C (2011) The Movement Disorder Society evidence-based medicine review update: treatments for the motor symptoms of Parkinsons disease

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