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Kucuk A, Baykara RA, Tuzcu A, et al

The glucagon receptor activation leads to a direct increase in energy expenditure, something neither Tirzepatide nor Cagrilintide can do (at least not as effectively)

Brain 127, 10611074

A greater proportion of PDAC-associated diabetes in NOD individuals occur within 0 to 12, 12 to 24, and 24 to 36 months prior to PDAC diagnosis, while similar proportions of PDAC-associated diabetes and control populations occur past 36 months, thus establishing the criticality of diabetes presentation 3 years before PDAC as a window of opportunity for early detection ( Figure 4A ) (91)

Compare that to typical discontinuation rates of 5% to 10% with GLP-1 receptor agonists