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Interestingly, loss of intracellular hydrogen peroxide or lipid hydroperoxides by overexpression of catalase or GPx-4, respectively, inhibits cell cycle progression from G 0 /G 1 - to S-phase (278, 377)

2 Some vaginal lubricants appear to slow sperm motility or have sperm-toxic effects, and therefore should be avoided or used sparingly

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While our recent studies in mice deficient in AGXT demonstrated enhanced steatohepatitis and hepatic fibrosis with significant enrichment of proinflammatory and profibrotic pathways 12,24 , the current RNA sequencing findings reveal that proinflammatory (chemokine signalling, cytokinecytokine receptor interaction, NF-B and TNF signalling) and profibrotic (focal adhesion signalling, regulation of actin cytoskeleton and ECMreceptor interactions) pathways are significantly suppressed in livers from mice overexpressing AGXT in hepatocytes during MASH