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Such a response is reminiscent of that of the daf-2 mutant, where daf-16 and xbp-1 act to maintain ER homeostasis (and increasing the lifespan) without inducing HSPs 66

k , Sunburst plot of differentially expressed genes belonging to biological process functional terms computed with SynGO

Metabolomic combined with transcriptomic analyses in primary hepatocytes showed that metabolic pathways, including long chain fatty acid metabolism, glycolysis, and glycogen metabolism, are also altered by HBV (74)