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Typically, CD4+ T cells secrete IL-2 and IFN- but chronic viral infections can significantly alter their cytokine profile to resemble those of their CD8+ counterparts with upregulation of programmed cell death protein 1 (PD-1) and downregulation of IL-2 and IFN- [90,91,92]

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Patients typically report fluctuating, widespread dull or aching pain, which may also include neuropathic characteristics such as burning or tingling

Mol Cell 52(4):602615 Yao JW, Ma Z, Ma YQ, Zhu Y, Lei MQ, Hao CY et al (2021) Role of melatonin in UV-B signaling pathway and UV-B stress resistance in Arabidopsis Thaliana

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