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Compared with traditional iron chelators (such as DFO), NPsLip-1 address issues related to rapid metabolism, poor targeting, and systemic toxicity (366)

Chronic ethanol consumption can induce oxidative stress-mediated apoptosis in neurons through the activation of caspases, a family of proteases that play essential roles in the programmed cell death process (Chen et al

Int J Mol Sci 24(9):8323 Gygi SP, Rist B, Gerber SA, Turecek F, Gelb MH, Aebersold R (1999) Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

doi: 10.1186/s42523-021-00107-2 232 PetersenC.RoundJ

While these agents share overlapping indications with glycyrrhizin, their mechanisms of action are distinct yet potentially complementary, offering opportunities for synergistic combination strategies in the management of liver diseases (Li et al., 2021)