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Additionally, tree-based ML algorithms such as XGBoost, LightGBM, and AdaBoost have been used to classify T2D patients based on metabolite data, achieving high accuracy and sensitivity in distinguishing T2D from non-diabetic controls (161)

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This paper thoroughly covers the origins, production, and metabolic pathways of TMAO, emphasizing its importance in the early detection and prognosis of human diseases in the Gut-Organ axis, as well as its mechanisms of influence on human diseases, particularly the cross-talk with cell death

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