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Supplementary material The Supplementary Material for this article can be found online at: References 1 AckermannJ.MerkelyG.MestrinerA

Typically, a hetNOE value for 1 H- 15 N the NH bond close to 1 indicates a more rigid conformation of the residue

N-Acetyl Epithalon Amidate represents a structurally modified form of this parent compound, incorporating N-terminal acetylation and C-terminal amidation two well-characterized peptide chemistry modifications designed to address the inherent instability of short-chain peptides in biological matrices

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Where copper peptides aggressively signal repair through one pathway, PDRN supports skin regeneration through DNA-fragment signalling that the skin recognises as familiar