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Metformin has been shown to reduce the accumulation of AGEs in the sciatic nerves of rats with streptozotocin (STZ)-induced diabetes by activating AMPK, leading to improved nerve conduction velocity, and the attenuation of heat and mechanical hyperalgesia (59)

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PACS2/CPT1A/DHODH signaling may function by modulating mitochondrial activity in cardiomyocytes ( 2.2.2.4 GTP cyclohydrolase 1/tetrahydrobiopterin The GCH1/BH4 pathway involves a fundamental enzyme participating in various critical cellular metabolic processes, with GCH1 being the rate-limiting enzyme for BH4 synthesis ( Figure 2B )