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In studies of neuroinflammation models (n = 7), both erinacine A and HEME protected N2a neuronal cells from lipopolysaccharide (LPS)-exposed BV-2 conditioned medium-induced cell death through the suppression of c-Jun N-terminal kinase (JNK) and nuclear factor kappa-light-chain-enhancer of activated B (NF-B) activation ( In primary cortical glia-neuron co-cultures, erinacine A improved neuronal and astrocyte survival and preserved astrocyte glutamate homeostasis in response to oxygen-glucose deprivation via the accumulation of glutamate transporter 1 protein levels ( tert -butylhydroperoxide-induced oxidative stress human neuroblastoma cell model ( In whole-brain mixed glia co-cultures following LPS insult, erinacine C induced the expression of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), which was correlated with increased protein expression of BDNF and other antioxidant enzymes ( Neurotrophic effects Under normal conditions, acute treatments with erinacine A, erinacine C, or erinacine S induced neurite-outgrowth of PC12 neurons in the presence of NGF, and also induced NGF release from astrocytic cells in 1321N1 cell models ( Summary In vitro studies on H

Yi and Hazell, 2006)

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The parties recently submitted a joint brief stating that ESI, the FTC, and Chairman Ferguson agree that former Chairwoman Khans departure does not affect ESI's allegations or claims beyond its request for an injunction to recuse Khan from FTC actions pertaining to ESI

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