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We had isolated primary microglia and treated them with MPP+ alone or in combination with Irisin

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This finding is consistent with prior evidence indicating increased glutamatergic transmission early in the illness but diminished glutamate in older or more functionally impaired cases [29,30,31,32,33,34,35,36,37]

For instance, TAMs exhibiting a high expression of the macrophage receptor with collagenous structure (MARCO) maintain the stemness of GBM stem cells (GSCs) by upregulating a set of stemness-associated factors such as leukemia inhibitory factor (LIF) and the homeobox protein NANOG

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