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Since 2001, many clinical trials have been conducted on omnivores to see if lowering homocysteine through pharmacological doses of folate, B12, and sometimes vitamin B6, could reduce the risk of cardiovascular disease, premature death, and cognitive decline

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the docked output for the 1-MQ analog 1j with an IC 50 value of 1.2 M was used to generate the predicted inhibitor-binding mode of 1j using the Auto Dock Tools (ADT) molecular graphics program

According to SUCRA values, the top two ranked administration routes were the oral route (78.3) followed by the IM route (49.6) (Table 3(B))