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High NNMT expression is closely associated with glucose dysregulation: excessive NNMT activation disrupts nicotinamide metabolism, lowers NAD+ levels, impairs insulin signaling, reduces cellular glucose uptake and utilization, and promotes hyperglycemia and insulin resistance

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This has left many people with one simple yet critical question, which is: Can Vitamin B12 deficiency be an indicator of cancer

Mullikin D, Pillai N, Sanchez R et al (2018) Megaloblastic anemia progressing to severe thrombotic microangiopathy in patients with disordered vitamin B12 metabolism: case reports and literature review