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Tissue healing occurs in stages, and the subjective experience of improvement may not track linearly with objective tissue changes

The driver may be mast-cell-mediated or systemic rather than NF-B-local, and if so, increasing the dose for additional KPV will not address it see the mast-cell note under Phenotype Considerations

Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34(+) hematopoietic stem cells from diabetic patients

Psychiatry 172 , 950966 (2015)