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Mice were initially group housed (three/cage) and allowed to acclimate to the colony environment maintained at a constant temperature (2123C) and humidity (4050%) on a 12-hour light-dark cycle (lights on 06001800 h)

Doubling the dose of MOTS-c wont resolve NAD+ depletion caused by NNMT overactivity, and increasing 5-Amino-1MQ wont activate AMPK if signaling pathways are suppressed

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Liver function monitoring will likely be included in routine clinical care but is not expected to require special frequency or intensity beyond standard medical practice

In contrast, an IV treatment immediately provides you with the necessary dose of the nutrient