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The profibrotic and proinflammatory mediators of SASP stimulate the infiltration of immune cells and tubular cell damage generating in persistent tubulointerstitial inflammation, the proliferation of fibroblasts, and extreme extracellular matrix deposition augmenting kidney damage and the progression to CKD

However, for deeper, more established pigmentation issues, optimal results typically require 3-4 months of consistent use

and after that neuronal damage

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