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a hinge domain/region of the present invention comprises or consists of the lgG1 hinge sequence DKTHTCPPCP (SEQ ID NO: 1449) (corresponding to the stretch D234 to P243 as shown in Table 1 below - variations of said sequence are also envisaged provided that the hinge region still promotes dimerization )

270 Recently, a group of reduced forms of vitamin K (VKH 2 ), including menaquinone and phylloquinone, was shown to have potent anti-ferroptosis properties, 21 providing new mechanistic insights into the anti-ferroptotic activity of alternative RTAs

Consistent with its role in promoting lipid peroxidation, treatment with 0.5 M of ML162 significantly elevated BODIPY intensity, and increasing the dose of ML162 to 1 M further enhanced BODIPY intensity (Fig

However, it can only be used for ex vivo tissue detection, and challenges in slicing adipose and bone tissues may reduce accuracy, while the complexity of the data adds to the difficulty of integration and analysis

Furthermore, we found that DNAC altered placental immune profile by stimulating macrophages to change to the M2 phenotype while decreasing the M1 phenotype, thus suppressing the inflammatory responses in the placenta