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[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Zuhra K., Augsburger F., Majtan T., Szabo C

It is an unapproved research chemical , not a medicine: its only controlled human trial (a Phase II study in postoperative ileus) failed its primary endpoint and development was discontinued, so the popular muscle, fat-loss, anti-aging, recovery and sleep claims are not proven in controlled human outcome trials presented for research and educational use only

J Pharmacol Res Dev

In patients with asthma, melatonin secretion is frequently dysregulated and has been associated with nocturnal symptom worsening ( Beyond its chronobiological role, melatonin exerts pleiotropic effects on immune and respiratory function ( A well-established but underexplored function of melatonin is its role in regulating cellular redox homeostasis

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