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The intrinsic factors (IFs) have the main role in the vitamin B12 transport

Our previous studies have reported similar evidence in hepatocytes with low B12 demonstrating upregulation of FA and TG synthesis [14], and increased adiposity via hypomethylation and upregulation of the master regulators of lipogenesis (SREBF1) and cholesterologenesis (LDLR) in adipocytes [13]

Since B12 is water-soluble, your body naturally processes and removes any extra amount it doesnt need

Semaglutide mimics a natural hormone in your body called GLP-1 (glucagon-like peptide-1)