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5.2.3 Bottlenecks and opportunities in clinical translation While ferroptosis-targeted strategies show promise in OA models, the translation to clinical settings remains hindered by key limitations in safety, efficacy, and delivery

We also observed that the binding of the E protein with TMED10 does not inhibit but rather enhances the association between TMED10 and IL1 (Supplementary Fig

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The polar active site has also contributed to ligand binding by forming ion-dipole interactions with Gln 33

From a therapeutic perspective, the central role of GPX4 is not equivalent to the only critical node