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A phase 2 trial (NCT02955290) is being done with a combination of nivolumab and pembrolizumab to test the overall survival along with progression-free survival in patients suffering from squamous cell carcinoma (SCC)

Thus, evidences suggest that diamidines interfere in the kinetoplast function of trypanosomatids through a selective association to the unique AT-rich regions of kDNA minicircles, perhaps involving DNA-processing enzymes [146]

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Pharmacokinetic studies showed that the modified M-NPs had higher blood retention and lower liver uptake, resulting in enhanced effectiveness for suppressing inflammatory cytokines in models of lipopolysaccharide-induced lung injury and endotoxemia