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doi: 10.1111/dth.12465

Fucoxanthin regulates Nrf2/Keap1 signaling to alleviate myocardial hypertrophy in diabetic rats

Three groups were vaccinated three times at three-week intervals with the following formulations: metE-DNA (100 g/100 L PBS/mouse), MetE protein alone (1 g/100 L PBS/mouse), and 1 g metE protein combined with AddaS03 adjuvant at a 1:1 volume ratio in a total of 100 L PBS/mouse, and AS01 adjuvant (5 g monophosphoryl lipid A [MPL]/5 g QS-21 in a total of 100 L PBS/mouse, representing 1/10th of the human dose of AS01)