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Tylenol toxicity, due to its narrow therapeutic window, is the leading cause of acute liver failure and results in approximately 30,000 hospital admissions in the United States annually

The prodrug strategies investigated thus far have aimed to mask negative charges by incorporating enzymatically cleavable hydrophobic chemical moieties that facilitate intracellular permeation

Begh, M

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For researchers and interested readers, monitoring registered clinical trial databases such as ClinicalTrials.gov and peer-reviewed preclinical journals remains the most reliable way to track meaningful new developments