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Based on the current understanding of the role of IFs, they cannot be simply regarded as a static scaffold network but are thought to participate in dynamic cell regulation by responding to extracellular signals and instantly remodeling local cellular structures

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A synthetic compound called carbonyl cyanide-m-chlorophenyl hydrazone (CCCP) was found to act as a decoupler that disrupts the proton motive force of the pump, resulting in an antibiotic-potentiating effect with tetracycline against Helicobacter pylori and Klebsiella , alleviating gastrointestinal tract-associated diseases 82,83