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Rare but serious risks include allergic reactions (including anaphylaxis in very rare cases), liver stress with prolonged high-dose use, and excessive skin lightening with unregulated dosing

Massive acetaminophen poisoning Massive poisoning may be defined as patients with any of the following: Clinical presentation A patient with high-risk ingestion may be critically ill early following the overdose and before hepatic failure develops due to parent-compound toxicity *

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Tests and models of nociception and pain in rodents