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While there are other GSTs capable of this conjugation reaction (notably in the alpha class), these other isoforms are much less efficient and their production is not induced by the stress events which cause the formation of 4-HNE (such as exposure to hydrogen peroxide, ultraviolet light, heat shock, cancer drugs, etc.), as the production of the more specific two isoforms is

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The dose would of course vary for someone who is physically castrate, most likely being lower

95 % CI (007, 071)

642 Currently, MAK683 is in a phase I clinical trial for treating diffuse large B-cell lymphoma (NCT02900651)