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Journal of Pharmacy and Nutrition Sciences, 2024

This imbalance of GSH homeostasis was also noted intracellularly within the AMs and was associated with decreased HDAC activities, increased apoptosis, and impaired phagocytosis

63,64 Accordingly, N1 neutrophils are typically characterized by a coordinated effector program that includes enhanced ROS generation, increased NETs formation, and elevated production of proinflammatory cytokines, together with transcriptional signatures enriched for chemokines, costimulatory and adhesion molecules