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& Castelo-Branco, G

Activation of the NLRP3 inflammasome represents a key step in IL-1 production during HIRI, further promoting neutrophil recruitment and amplification of the inflammatory response (45)

UA levels also have the potential to serve as a promising biomarker for identifying individuals at high risk of neurodegenerative diseases and could be a novel target for pharmacological therapy

Furthermore, in vitro and in vivo models of intracerebral hemorrhage were created by treating BV2 cells with hemoglobin and intraventricular injection of type IV collagenase into Sprague-Dawley rats, respectively