melanotic neuroectodermal tumor of infancy wiki Frontiers Melanotic Neuroectodermal Tumour of Infancy

doi: 10.1172/JCI153247 50 PearceELWalshMCCejasPJHarmsGMShenHWangLSet al

doi: 10.3389/fnut.2025.1696066 Received 31 August 2025 Revised 01 December 2025 Accepted 05 December 2025 Published 23 January 2026 Volume 12 - 2025 Edited by Jianmei Li, Nanjing Normal University, China Reviewed by Peng-Yu Zhong, Nanchong Central Hospital, China Uttam Khatri, The University of Texas at Austin, United States Updates Copyright 2026 Jin, Zhai, Bai, Hu, Yu, Sang, Wu and Hao

In neurons and astrocytes roxadustat provoked a HIF-1-dependent glucose metabolism reprogramming including elevation of glucose uptake, glycogen synthesis, glycolytic capacity, lactate production and lactate release, which enhanced the ischemic tolerance of astrocytes, but not neurons

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