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These effects may be magnified in individuals with chronic diseases that have an inflammatory component (e.g., obesity, diabetes, heart disease), as well as in those with age-related, low-grade inflammation, also known as inflammaging

Stromal cell-derived factor-1 (SDF-1) promotes chondrogenic differentiation and migration of CXCR4 NPPCs while enhancing aggrecan and collagen II synthesis [82]