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J Clin Gastroenterol 2021;55:586-93.PubMed 111

Acknowledgements N.L.M is supported by a Wellcome Trust Postdoctoral Fellowship (WT100651MA) and grants from Arthritis Research UK (Ref 21346) and the Royal College of Surgeons of Edinburgh

S6L), indicating that the treatment was not toxic to the animals

Important translational barriers persist, including limited clinical validation, fragmented mechanistic understanding across isolated pathways, and pharmaceutical limitations such as poor solubility, rapid metabolism, and batch variability that reduce reproducibility