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Kresser C

between 2 to 5% of all O 2 consumed by the organelle is used for the production of ROS ( 2 O 2 and O 2 - ), mainly through Complexes I (NADH-ubiquinone oxidoreductase) and III (ubiquinone: cytochrome c oxidoreductase) (Mller, 2001

The analysis performed with the functional mimic FhbA suggest weaker binding of the aptamers compared to CspZ, with binding in the M range, characterized by lower association rate (particularly for aptamers 3, 7, and 10) and higher dissociation rate

These functions place them at the center of pathophysiological conditions such as hypoxia-induced injury, inflammation, neurodegeneration, aging, and cancer (Nemkov et al., 2018)