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Instead, the selected literature was analyzed and synthesized thematically, with studies grouped according to biological pathways (e.g., monoaminergic modulation, neurotrophic signaling, HPA-axis regulation, neuroinflammation, oxidative stress, and mitochondrial function) and level of evidence (preclinical versus clinical)

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Falutz J, Mamputu JC, Potvin D, et al.: Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in human immunodeficiency virus-infected patients with excess abdominal fat: A pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials with safety extension data