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We assumed that DHA oxidizes Cys20 and that the oxidation would affect the affinity of ascorbate

The N-terminal domain contains the activation function 1 domain (AF-1) that recruits co-regulators in a ligand-independent manner, while the ligand-binding domain contains a second transactivation domain (AF-2) that serves as a platform for a different set of ligand-dependent coregulators (20, 21)