penile melanotic macule Mystery behind labial and oral macules: Clinical, dermoscopic and pathological aspects of Laugier-Hunziker syndrome Freckles, Lentigos, Melanocytic Nevi, and

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Melanosis coli is a darkening of the colonic mucosa caused by the accumulation of lipofuscin particles within the macrophages of the lamina propria of the colonic mucosas a result of long term exposure to anthraquinone-containing laxatives

occurrence of reducing sugars), this mechanism may be even most relevant than ROS-mediated carbonylation (Luna and Estvez 2019

It results from a localized accumulation of melanin in the basal epithelial cells, without an increase in the number of melanocytes themselves

95% CI 1.02-1.23)