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Examples of drugs that can cause serotonin syndrome when combined with cyclobenzaprine include, but are not limited to: Selective serotonin reuptake inhibitor (SSRI) antidepressants used for depression or anxiety, such as Lexapro (escitalopram), Paxil (paroxetine), Zoloft (sertraline), or Prozac (fluoxetine) Serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants such as Cymbalta (duloxetine) or Effexor (venlafaxine) Tricyclic antidepressants such as Elavil (amitriptyline) or Pamelor (nortriptyline) Monoamine oxidase inhibitors (MAOIs) such as phenelzine or tranylcypromine Opioid pain medications such as Ultram (tramadol), OxyContin (oxycodone), or Demerol (meperidine) Wellbutrin (bupropion) Triptans for migraine, such as Imitrex (sumatriptan) or Maxalt (rizatriptan) St