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Although a balanced diet including a variety of foods will generally supply enough vitamin B12 for most people, supplementation is sometimes necessary for certain age groups and circumstances or for those with underlying health conditions

Future studies may clarify optimal dosing strategies and identify populations that benefit most from bicarbonate-based hydration protocols

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In mitochondria, Vitamin B12 acts as a cofactor for methylmalonyl-CoA mutase , an enzyme that catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA

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