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Revollo et al., 2007

In summary, the Western-style diet promotes a cascade of pathophysiological eventsgut dysbiosis, systemic inflammation, BBB disruption, neuroinflammation, and protein misfoldingthat converge to drive the onset and progression of Alzheimers disease

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When this regulation is impaired or metabolic transitions are inefficient, it can negatively impact physiology, leading to a variety of diseases and disorders 1