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Vitamin B12 supplements are usually given by injection at first

Pro-inflammatory cytokines, including IL-6, IL-1, and TNF-, promote M1-type TAM formation, inhibit iron release into the tumor immune microenvironment (TIME), and exert anti-tumor effects ( + ) bind to FT for transport throughout the body

The risks associated with vitamin B12 deficiency

Nowadays, there is an increasing attempting to determine the possible penetration pathways because, with this information in hand, researchers are able to propose some structural modifications in the delivery systems, aiming to improve the skin penetration into the target tissue and, consequently, the pharmacological action of the drug [56]