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In addition, a study conducted in BV2 murine microglia cells, which served as a representative cell specimen for brain microglia, showed that the upregulation of antioxidant/detoxification proteins by SFN was associated with enhanced resistance of microglial cells to heat-induced toxicity and removal of ROS during microglial cell activation (90)

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Immunological studies typically use membrane-incorporated dyes, or genetic switches that result in constitutive fluorochrome expression if a cell marker is expressed

In vivo studies in rats demonstrated no hemolysis, platelet aggregation, or acute toxicity, confirming the biocompatibility of the polymeric NPs

Several studies have suggested the involvement of connexin and hemichannel signaling in APAP-induced acute liver failure