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However, accumulating evidence suggests that many AAs historically classified as non-essential exhibit essential functions under pathological or stress conditions, and are now referred to as conditionally essential amino acids (CEAAs) (Hou et al

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These early studies predated modern receptor-binding assays, molecular signalling techniques, and epigenetic methodologies, limiting mechanistic resolution but providing essential chemical and pharmacological context

In addition to TYMP mutations, MNGIE-like phenotypes can also arise from mutations in other genes

Front Med (Lausanne)