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Broadly, NTFs can be classified into four major families: the neurotrophins (e.g., nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], neurotrophin-3 [NT-3], and neurotrophin-4 [NT-4]), the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs, e.g., GDNF, Neurturin [NRTN]), the neuropoietic cytokines (e.g., ciliary neurotrophic factor [CNTF]), and other factors including cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) [11]

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Understanding these aspects is crucial for developing strategies to optimize the immune environment and improve long-term graft survival[42]

232 Similarly, overexpression of the transcription factor SOX2 in squamous lung cancer promotes TAN accumulation via upregulating of CXCL5, the murine homolog of human CXCL6